【摘要】 目的:比较瑞波西汀与氟西汀治疗老年抑郁症的疗效和安全性。方法:用瑞波西汀与氟西汀对144例老年抑郁症患者进行为期6周的随机对照试验,用汉密顿抑郁量表(HAMD)评定疗效,用不良反应量表(TESS)评定不良反应。结果:瑞波西汀与氟西汀治疗老年抑郁症的疗效相当(P>0.05),其显效率分别为72.3%和75%;瑞波西汀致口干、便秘、皮肤异样感等不良反应较氟西汀多,而恶心、呕吐、腹泻、嗜睡等不良反应较氟西汀少。结论:瑞波西汀治疗老年抑郁症具有良好的疗效和安全性。更多还原

【Abstract】 Objective:To compare the efficacy and safety of reboxetine and fluoxetine in the treatment of senile depression.Meth- od:One hundred and fourty-four patients were randomly assigned to receive reboxetine (n=72)and fluoxetine(n=72) for 6 weeks. Their efficacy were evaluated by Hamilton Depressine Scale (HAMD) and their adverse reactions were evaluated by the Treatment E- mergent Symptom Scale(TESS).Result:The efficacy of reboxetine and fluoxetine were nearly equal.The effective rates of reboxetine and fluoxetine was 72.3% and 75%,respectively.The ADR rates of dry mouth,constipation,abnormal skin perception of rebxefine were higher significantly than that in fluoxetine,but nausea,vomiting,diarrhea,somnolence were lower than that in fluoxetine.Con- clusion:Reboxetine has good efficacy and safety in treating senile depression.更多还原