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埃索美拉唑治疗消化性溃疡的临床研究
Clinical Study on Therapeutic Effect of Esomeprazole in Treatment of Peptic Ulcer
【摘要】 目的:为探讨埃索美拉唑联合抗生素治疗幽门螺杆菌(Hp)感染消化性溃疡的疗法。方法:将符合条件的122例病人,随机分为埃索美拉唑三联治疗组(A组)和奥美拉唑三联对照组(B组)。治疗4周后,复查胃镜并检测Hp,观察两组溃疡愈合率及Hp根治率。结果:A组和B组Hp根治率分别为92.31%(60/65)和91.23%(52/57),两组比较无统计学差异(P> 0.05)。A组和B组溃疡愈合率比较无统计学差异(P>0.05)。结论:埃索美拉唑三联疗法能有效的清除Hp及提高溃疡愈合率,是一种根治坳有高效、副作用少的药物。
【Abstract】 Objective:To study the effect of esomeprazole and omeprazole triple therapy on peptic ulcer.Method:The patients with peptic ulcer were divided randomly into esomeprazole triple therapy group (A group) and omeprazole triple therapy guoup (B group).After the treatment was used for 4 weeks,gastroscopy and Helicobacter pylori(Hp) were reexamined.Healing rate of peptic ul- cer and eradication rate of Hp were observed in two groups.Result:Healing rate of group A and group B had no statistical difference, Eradication rate of Hp in group A and group B was 92.31% and 91.20%,respectively.It had no statistical difference(P>0.05). Conclusion:The effect of esomeprazole triple therapy is effective in the treatment of peptic ulcer and the side-reaction is low.
【Key words】 Esomeprazole; Omeprazole; Clarithromycin; Amoxicillin; Peptic ulcer;
- 【文献出处】 中国药师 ,China Pharmacist , 编辑部邮箱 ,2008年04期
- 【分类号】R573.1
- 【被引频次】4
- 【下载频次】94