【摘要】 目的:研究和探讨慢性肝炎患者血清PDGF、TGF-β含量与慢性肝炎不同证型之间的关系。方法:根据辨证设慢性肝炎肝郁脾虚、湿热中阻、瘀血阻络3组各30例和正常对照组30例,采用酶联免疫吸附法(ELISA)检测不同证型慢性肝病患者血清PDGF、TGF-β的含量。结果:肝郁脾虚等3组PDGF、TGF-β含量阳性率均高于正常对照组,差异有显著性;瘀血阻络证组高于肝郁脾虚、湿热中阻,差异有显著性;定量水平结果亦与其相符;肝炎程度不同,其PDGF、TGF-β水平也不同,差异有显著性。结论:慢性肝炎不同证型肝纤维化程度不同,与PDGF、TGF-β水平有较强的关联。更多还原

【Abstract】 Objective:To study the relationship between TCM′s syndrome differentiation typing and serum levels of PDGF and TGF-β in chronic hepatitis.Methods:90patients suffering from chronic hepatitis were divided into 3 groups according to the TCM′s typing,including liver depression and spleen deficiency syndrome group(30cases),middle energizer dampness-heat syndrome group(30cases)and blood-stasis obstruction syndrome group(30cases).And control group(30 healthy persons)was established.The serum concentration of PDGF and TGF-β of the 120 persons was detected by ELISA.Results:The serum concentration of PDGF and TGF-β in the patients was higher than that in healthy persons.The serum concentration of PDGF and TGF-β in blood-stasis obstruction syndrome group was higher than that in the group of liver depression and spleen deficiency syndrome and middle energizer dampness-heat syndrome.The quantitative level was accordant with above qualitative level.The serum levels of PDGF and TGF-β was different in various degree hepatitis.The difference was significant in all above situation.Conclusion:Various TCM′s syndrome of chronic hepatitis are different not only in macroscopic diagnostic indexes but also in microcosmic indicator.It is strongly relative with the PDGF and TGF-β.更多还原