【摘要】 目的:研究低频电针(2Hz)足三里对酒依赖大鼠饮酒行为的影响。方法:共24只SD大鼠(酒依赖模型组18只,对照组6只)。采用6%(v/w)的酒精水溶液作为SD大鼠唯一的饮水来源共30天建立酒精躯体依赖模型,进一步将其分为戒断组、捆绑组、电针组各6只大鼠。分别对酒精依赖大鼠进行急性(电针一次)和慢性(电针六次)低频电针足三里处理,观察急慢性电针对大鼠饮酒量和酒精偏爱程度(酒精/水自由选择)的影响。结果:急性电针足三里处理大鼠饮酒量和酒精偏爱组间比较差异有显著性(F(2,15)=7.034,P=0.007;F(2,15)=4.810,P=0.024),电针组饮酒量和酒精偏爱较对照组(捆绑对照和非捆绑对照)均降低,其中三组饮酒量和酒精偏爱均值和标准差分别为(4.2±0.4,9.6±0.9,8.0±0.7)及(4.3±0.2,7.5±0.7,7.8±0.7);差异有统计学意义(P<0.001)。慢性电针足三里处理后大鼠饮酒量和酒精偏爱程度与对照组(捆绑对照和非捆绑对照)比较均无显著性差异。结论:急性低频电针足三里能抑制酒精依赖大鼠的饮酒行为。更多还原

【Abstract】 Objective:To evaluate the effects of low frequency electroacupuncture(EA)at Zu San-Li on ethanol taking behavior in ethanol dependent rats.Methods:18 Rats were made ethanol-dependent by supplying ethanol solution(6%,v/w)as the sole drinking source for 30 days.Total ethanol intake and ethanol(6%)/water choice preference were measured after acute(one time)or chronic(six times)EA at Zu San-Li.Two control groups were set as constrained control,non-constrained control.Results:There were significant differences in both total amount of ethanol intake and ethanol preference(ethanol/water free choice)among three groups after acute EA at Zu San-Li(F(2,15)=7.034,P =0.007;F(2,15)=4.810,P=0.024).The rats received acute EZ had lower ethanol intake and ethanol preference than the two control groups(4.2±0.4,9.6±0.9,8.0±0.7 and 4.3±0.2,7.5±0.7,7.8±0.7;P<0.001),but this effects were not observed after chronic EA treatment.Conclusion:Acute low frequency EA at Zu San-Li could attenuate ethanol intake and preference in ethanol-dependent rats.更多还原