【摘要】 目的:研究非痴呆的帕金森(PD)病人多种学习记忆任务的损害程度。方法:采用程序性学习测试软件(SRTT)、外显记忆项目(采用韦氏记忆量表)和内隐记忆项目(采用程氏编制的多维记忆量表中的自由组词和残图命名)对16例Hoehn-Yahr分级I～Ⅱ级的PD患者施测,其中程序性学习测试设置了正常对照组。结果:未发现PD组患者韦氏记忆量表记忆商(97.1±10.6)较常模有统计学意义的改变,内隐记忆项目(自由组词测试11.2±4.8,残图命名9.5±2.9)亦无统计意义的改变;正常组SRTT反应时随着学习节数增加明显缩短(F=2.54,P=0.008),错误率从第2节起显著下降,第2节任务操作错误率低于第1节((3.2±0.9)%to(6.8±2.7)%,t=-2.08,P=0.045),PD组第1节任务操作错误率高于第3节((4.7±2.0)%to(3.7±1.8)%,t=-2.15,P=0.038),但起自第3节,反应时改变无统计学意义。总的操作错误率PD组高于正常组((5.0±2.2)%/(4.4±1.30),(t=1.61,P=0.10)。结论:程序性学习任务SRTT测试发现PD患者有选择性损害,而其他记忆项目如韦氏记忆量表、自由组词和残图命名评分则无异常。提示所测试的学习记忆有分离现象。更多还原

【Abstract】 Objective:To study memory changes in patients with non-demented Parkinson disease(PD) without depression.Methods:The Nissen Version(serial reaction time task,SRTT) software(as a task of procedural learning),the WMS-CR and two tasks of implicit memory were applied in 16 PD patients(Hoehn-Yahr score I~Ⅱdegrees).Normal controls enrolled for the Nissen Version either.Results In the explicit WMS-CR and the implicit(word stem completion and degraded picture naming) tasks,the patients’ scores fell within normal limits(Memory Quotient 97.1±10.6).In the SRTT,normal control group displayed significantly reduced response times(F=2.54,P=0.008) and error rates(3.2 ±0.9% to 6.8 ±2.7%,t=-2.08,P=0.045) across the blocks of repeated sequence trials.By contrast,PD patients only showed a reduction in error rates(4.7±2.0% to 3.7±1.8%,t=-2.15,P=0.038) but no change in response times.Conclusion:Impairment of nigrostriatal pathways selectively affects performance in visuo-motor learning tasks such as the SRTT,but not in the explicit tasks of WMS-CR and the implicit tasks such as word stem completion and degraded picture naming.更多还原