【摘要】 Bcl-2家族蛋白在细胞凋亡的调节中起着重要的作用,髓样细胞白血病-1(Mcl-1)是Bcl-2家族中一个重要的抗凋亡成员,并作为促耐药因子在不同肿瘤组织中表达。进展期肝细胞癌对各种化疗药物有着高度的耐药性,Mcl-1下调使HCC癌细胞对不同化疗药物敏感,并增加癌细胞的凋亡率。因而,Mcl-1靶向治疗有望成为肝细胞癌治疗的新途径。更多还原

【Abstract】 Bcl-2 family proteins play a critical role in the regulation of apoptosis. The myeloid cell leukemia 1 (Mcl-1) is a potent anti-apoptotic Bcl-2 family member which has been reported as a resistance factor in various types of cancer. Advanced hepatocellular carcinoma (HCC) is highly treatment resistant to various chemotherapeutic modalities. Down-regulation of Mcl-1 increases chemosensitization and apoptosis of HCC cells. Therefore, targeting Mcl-1 might qualify as a promising novel approach in HCC therapy.更多还原