【摘要】 目的研究醛固酮合成酶(CYP11B2)基因T-344C单核苷酸多态性(SNP)在中国人群中的分布。方法采用PCR-RFLP法对中国人群进行醛固酮合成酶(CYP11B2)基因T-344CSNP频率分析比较。结果中国人群的醛固酮合成酶(CYP11B2)基因T-344C基因型频率分布:TT型占64.5%,TC型占30.8%,CC型占4.7%;等位基因频率T占79.9%,C占20.1%。各基因型频率、等位基因频率与西班牙人、德国人、苏格兰人、日本人差异非常显著。结论醛固酮合成酶(CYP11B2)基因T-344CSNP频率的分布有明显的种族差异。更多还原

【Abstract】 [Objective] To observe the distribution of T-344C SNP (single nucleotide polymorphism) of CYP11B2 gene in normal population in China. [Methods] The frequency of T-344C SNP of CYP11B2 genotype was detected by PCR-RFLP in normal Chinese people. [Results] In normal people in China, the frequencies of T-344C SNP of CYP11B2 genotype were TT 64.5%,TC 30.8%, CC 4.7%. The allelic genotype frequency of T was 79.9%, C was 20.1%. The frequencies of the genotypes were significantly different from those of Spanish, German, Scottish, Japanese. [Conclusion] T-344C SNP genotype frequency of CYP11B2 varies among different races and people.更多还原