【摘要】 目的:探讨多发性肌炎(PM)/皮肌炎(DM)患者血清中抗Jo-1,Mi-2,PL-7,PL-12肌炎特异性抗体(MSA)及抗PM-SCL,Ro-52肌炎相关性抗体(MAA)的临床意义。方法:选取36例确诊为PM/DM患者,利用欧蒙免疫印迹法检测其血清中这6种抗体,并计算出血清MSAs和MAAs的阳性率,分析患者的临床表现、疾病活动性及预后与自身抗体的相关性。结果:36例患者中22例出现MSAs和(或)MAAs阳性(61%),其中MSAs阳性率为40%,最常见的MSAs是抗Jo-1抗体(30%),MAAs的阳性率为28%,抗Ro-52抗体占18%,并且与抗Jo-1抗体高度相关。结论:MSAs和MAAs在PM/DM患者中阳性表达率较高,MSAs与PM/DM的临床表现、疾病活动性和预后相关。更多还原

【Abstract】 Objective:Purpose Determinate polymyositis(PM)/dermatomyositis(DM) in the serum of patients with anti-Jo-1,Mi-2,PL-7,PL-12 polymyositis specific antibody(MSA) and anti-PM-SCL,Ro-52 myositis associated antibody(MAA),the positive rate on its PM/DM in significance.Methods:36 cases diagnosed as PM/DM patients with serum using oumeng immunoblotting test the serum of patients with anti-Jo-1,Mi-2,PM-SCL,PL-7,PL-12,Ro-52 antibody,and calculated serum MAAs MSAs and the positive rate of patients with clinical manifestations,and prognosis of disease activity and the associated autoantibodies.Results:36 cases with 22 cases of MSAs and(or) MAAs positive(61%),which MSAs positive rate was 40 percent,the most common MSAs was the anti-Jo-1 antibody(30%),MAAs the positive rate was 28%,Anti-Ro-52 antibody for 18 per cent,and with the anti-Jo-1 antibody highly relevant.Conclusion:MSAs and MAAs in PM/DM patients with high positive rate,MSAs with PM/DM of clinical performance,disease activity and prognosis.更多还原