【摘要】 目的对五苓散(WLS)的长毒作用进行评价。方法观察给药后大鼠的一般症状、血液学、血液生化学、系统尸检和恢复期的有关指标,对WLS进行安全毒理学评价。结果对血液学及血液生化指标有一定的影响,主要表现在白细胞数分类及血红蛋白的改变(有统计学意义),但停药后基本恢复。三个剂量组大鼠的心、脾、肺、肾上腺、前列腺、卵巢、子宫或睾丸(连附睾)、脑等脏器系数均无明显改变。结论临床应用需注意肝、肾脏和睾丸等脏器的毒性表现。更多还原

【Abstract】 Objective The aim of this work was to evaluate the long-term toxic effects of WLS.Methods Targets were observed after oral administration of WLS.Results Some targets were influenced after oral administration of WLS(P<0.05).Conclusion The toxic effects of some organ such as liver,kidney and testicle should be paid attention when it used in clinical therapy.更多还原