【摘要】 目的:探讨急性白血病患者化疗前后白介素-2(IL-2)及白介素-6(IL-6)水平变化对免疫功能影响的临床意义。方法:应用放射免疫分析法对57例急性白血病患者进行化疗后血清IL-2及IL-6含量检测,并与30例正常健康人作对照。结果:急性白血病初治组及短期完全缓解(CR)组IL-2水平分别为(18.69±9.41)ng/L,(29.36±6.30)ng/L,明显低于长期CR组(46.71±8.23)ng/L及正常对照组(53.62±8.86)ng/L;初治组及短期CR组IL-6水平分别为(125.86±15.78)ng/L,(82.27±10.21)ng/L,明显高于长期CR组(30.29±7.63)ng/L及正常对照组(23.46±6.32)ng/L。初治组IL-2和IL-6水平与长期CR组及正常对照组比较差异有显著性,P<0.05。结论:初治及短期CR急性白血病患者IL-2水平低、IL-6水平高,造成免疫抑制状态,白血病易复发。随着CR时间的延长,免疫状态逐渐恢复。更多还原

【Abstract】 Objective:To probe into the clinical significance of influence of the changes of interleukin(IL)-2 and IL-6 on immune function of acute leukemia(AL) patients before and after chemotherapy.Methods:With the radio-immuno-assay(RIA) used,the contents of IL-2 and IL-6 in the serum of 57 cases AL patients after chemotherapy were tested,which had been compared with 30 cases healthy persons.Results:The levels of IL-2 in AL initial treatment group and short-term complete relief(CR) group were respectively(18.69±9.41)ng/L and(29.36±6.30)ng/L,which were obviously lower than those in long-term CR group(46.71±8.23)ng/L and healthy control group(53.62±8.86)ng/L.The levels of IL-6 in AL initial treatment group and short-term CR group were respectively(125.86±15.78)ng/L and(82.27±10.21)ng/L,which were obviously higher than those in long-term CR group(30.29±7.63)ng/L and healthy control group(23.46±6.32)ng/L.The levels of IL-2 and IL-6 in initial treatment group had significant differences comparing with those in long-term CR group and healthy control group(P<0.05).Conclusion:Of the AL patients in initial treatment group and short-term CR group,the level of IL2 is low and IL-6 is high,by which the immuno-suppression condition will be formed and the AL is easy to recur.With the extending of CR time,the immune condition will gradually recover.更多还原