【摘要】 目的利用磁共振弥散张量成像技术探讨重性抑郁症患者脑白质纤维是否存在性别差异。方法24例重性抑郁症患者(男15例,女9例)及30名正常对照(男11名,女19名)均经常规核磁共振(MRI)和DTI扫描,基于像素的全脑分析技术对各组间DTI数据进行比较分析。结果男性患者左额中回、右颞叶回下、左梭状回、楔前叶及右顶叶回下等区域各向异性值(faraction anistropy,FA)低于男性正常对照(P<0.001);女性患者在右额上回、额叶回下、颞叶回下、左颞上回及右后扣带回等白质区域的FA值低于女性正常对照(P<0.001)。②女性患者在右顶叶回下、左中央前回、右颞中回及右扣带回白质区域的FA值低于男性患者(P<0.001);女性正常对照仅在左边缘叶下回及左枕叶中回的区域的FA值低于男性正常对照(P<0.001)。结论男女抑郁症患者均存在脑白质异常区域,且两者之间存在差异。更多还原

【Abstract】 Objective To investigate the gender difference of the white mater integrity between patients with major depressive disorder(MDD)and the healthy controls by diffusion tensor imaging(DTI).Methods Twenty-four patients with MDD(male 15,female 9)and thirty healthy controls(male 11,female 19)were underwent conventional magnetic resonance imaging(MRI)and DTI scanning and,DTI data were analyzed using whole-brain voxel-based analysis(VBA)method.Results Compared with male healthy controls,the male patients had significantly decreased fractional anisotropy(FA)in the left middle frontal gyrus,the right sub-gyrus of the temporal,the left fusiform gyrus,precuneus and sub-gyrus of the right parietal lobe(P<0.001);Compared with female healthy controls,female patients had significantly decreased FA in the right superior frontal gyrus,sub-gyrus of the frontal gyrus,temporal sub-gyrus,left superior temporal gyrus and right posterior cingulate(P<0.001);Compared with male patients,female patients had significantly decreased FA in the right sub-gyrus of the parietal lobule,left middle temporal gyrus,left precentral of the frontal lobe,right cingulate gyrus of the limbic lobe(P<0.001);Compared with male subjects,the healthy female controls had significantly decreased FA only in the left middle occipital gyrus(P<0.001).Conclusions Both male and female patients with MDD have abnormal white matter integrity regions.更多还原