【摘要】 目的:探讨共轭亚油酸镁硒复方制剂(CMS)对食高脂饲料小鼠的减肥作用。方法:选昆明种小鼠63只,随机分为5组,正常对照组10只,模型对照组14只,高、中、低剂量组各13只。正常对照组给予基础饲料,模型对照组和实验组给予高脂饲料,实验组同时按0.2mL/10gBW经口灌胃给予1.5%的羧甲基纤维素CMS水溶液,模型对照组和正常对照组给予相同的1.5%的羧甲基纤维素水溶液。实验4周后,称体重和睾丸周围脂肪量,计算饲料利用率,测定血清甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、总胆固醇(CHO)、血糖(GIU)。结果:与模型对照组相比,CMS中剂量组体重明显降低(P<0.05),高剂量组极明显降低(P<0.01);睾丸周围脂肪重量、脂体指数CMS3个剂量组极明显降低(P<0.01),食物摄入量没有明显变化。结论:CMS有降低食高脂饲料胖鼠体重、脂肪的作用。更多还原

【Abstract】 Objective:To study the effect of conjugated linoleic acid magnesium selenium(CMS) on body weight reduction in mice fed by high-fat diet.Methods:63 male Kunming mice were randomly divided into five groups,i.e.normal control group 10,model control group 14,low,middle and high dose groups 13 for each,and fed basal diet for the normal control group,fed high-fat diet for others.At the same time,0.2 mL/10g BW 1.5%CMC+CMS aqueous solution were given orally for three dose groups daily,and 0.2 mL/10 g BW 1.5%CMC aqueous solution for the others.After four weeks,body weight,testis fat were weighed,food consumption and serum TG,HDL,CHO,GIU were measured.Results:The body weight were lower significantly for middle dose group(P<0.05) and high dose group(P<0.01),testis fat weight and index of testis fat weigh/body weight were lower significantly for three dose groups(P<0.01),food intake consumption had no obvious change compared with the model control.Conclusions:CMS is effective in lowering body weight and body fat in mice fed by high-fat diet.更多还原