【摘要】 目的:探讨酒肝清胶囊治疗酒精性脂肪肝的药理作用。方法:Wistar大鼠每次ig 56度白酒5 mL.kg-1;每日2次。连续4周,造成脂肪肝模型,大鼠肝脏经病理组织学检查,证明模型成立后,开始分组给药。模型组每日ig 56度白酒5 mL.kg-1;阳性药组每日ig 25 mg.kg-1绞股蓝总甙和56度白酒5 mL.kg-1;酒肝清胶囊高,中,低剂量组每日ig 0.6,0.3,0.15 g.kg-1酒肝清胶囊,同时ig 56度白酒5 mL.kg-1,每日1次,连续4周。取血清,测定谷丙转氨酶(ALT)、谷草转氨酶(AST)、甘油三酯(TG)、总胆固醇(T-CHO)、超氧化物歧化酶(SOD)、丙二醛(MDA)、总蛋白(TP)、白蛋白(Alb)和肿瘤坏死因子(TNF-α)含量。取肝脏称重,计算肝脏系数(g.100 g-1体重)。取肝左叶,测定TG,TC,MDA,ALT,AST,SOD活性。取肝右叶,做病理检查。结果:酒肝清胶囊灌胃给药,可以显著降低酒精性脂肪肝大鼠TG,TC,ALT,AST,MDA和TNF-α含量,增加ALB含量和SOD活性。结论:酒肝清胶囊对大鼠实验性酒精肝有明显的治疗作用。更多还原

【Abstract】 Objective:To investigate the effect of Jiuganqing capsule on alcoholic fatty liver.Methods:Alcoholic fatty liver of Wister rat was in duced by ig 56° alcohol liquid 5 mL·kg^-1 twice a day for 4 week.The model is determined by histopathologic examination.The model group was given alcohol liquid as mentioned above.The masculine drug group was given Gypenosides ig 25 mg·kg^-1 daily and alcohol as the model.Jiuganqing capsule high,middle and low dose-group was separately give ig 0.6,0.3,0.15 g·kg^-1 and alcohol as the modes for 4 week.The content of ALT,AST,TG,T-CHO,SOD,MDA,TP,Alb and TNF-a in serum were detected.The hepatic index was calculated by weighing liver.The activity of TG,TC,MDA,ALT,AST and SOD in hepatic hemogenate were detected.Results:Jiuganqing capsule can obviously reduce activity of ALT,AST and the content of T-CHO、TG、MDA,TNF-α but increase the content of Alb and activity of SOD.Conclusion:Jiuganqing capsule has obviously therapeutic effect on alcoholic fatty liver in rat.更多还原