【摘要】 目的:建立肠球菌毒力相关性兔心内膜炎模型,用于肠球菌类毒力因子的研究。方法:用粪肠球菌(Enterococcus faecalis)标准毒株OG1RF和粪肠球菌sprE基因缺陷突变株来建立兔心内膜炎模型,通过心内膜炎相关指标的检测来判断毒力下降情况。结果:突变株在兔心内膜炎模型中产生赘生物的大小、重量以及菌落计数都明显低于标准株。结论:肠球菌毒力相关性兔心内膜炎模型建立成功,可用于肠球菌其他可能毒力因子的研究。更多还原

【Abstract】 objective:To establish Rabbit endocarditis models caused by Enterococcus faecalis for studying virulence of Enterococcus.Methods:Standard strain OG1RF and sprE gene deficient mutant of Enterococcus faecalis were used to establish Rabbit endocarditis models.The index of endocarditis was detected to show virulence change.Results:The size,weight and Colony count of vegetation of sprE mutant groups were smaller than those of wild-type OG1RF groups in a rabbit endocarditis model.Conclusion:The Rabbit endocarditis models caused by Enterococcus were establised successfully,which would be used to study other virulence factor of Enterococcus faecalis.更多还原