【摘要】 目的分析影响甲状腺髓样癌(MTC)生存率的预后因素,探讨提高MTC生存率的治疗措施。方法回顾性分析14年间收治的MTC手术切除患者33例的临床资料,选择8项临床、病理学因素,分析其对生存率的影响。结果总的5年生存率为63.03%。单因素分析示:年龄、淋巴结转移、远处转移、肿瘤分期和根治切除程度等5项指标与预后有关。多因素分析示:不同年龄及不同的根治切除程度,其生存率组间差异有显著性,说明这两因素与生存率有关。结论年龄、根治切除程度是影响MTC患者生存的独立预后因素。老龄甲状腺肿瘤应警惕MTC的存在。保证肿瘤根治切除的彻底性是提高MTC生存率的关键。更多还原

【Abstract】 Objective To evaluate the prognostic factors of of medullary thyroid carcinoma(MTC),and explore the treatment measures on increasing survival rate.Methods The records of 33 MTC patients treated at our hospital in past 14 years were retrospectively analyzed.The effects of clinical and pathological factors on the overall survival rate were evaluated by univariate and multivariate analyses.Results The overall 5-year survival rate was 63.03%.Based on univariate analysis,age,lymph node invasion,distant metastasis,tumor stage,and the extent of primary surgical resection were related with prognosis.In multivariate analysis,however,only age and the extent of the primary surgical resection were found to be statistically significant factors related to survival.Conclusions The extent of the primary surgical resection and age are independent predictors of survival of patients with MTC.Vigilance of MTC in old patients with thyroid neoplasm and ensurance of radical tumor operation are the key points for increasing the overall survival of MTC.更多还原