【摘要】 目的利用亲水性的Eudragit系列高分子物质单用、与疏水性的乙基纤维素合用制备齐多夫定骨架型缓释片。方法确定5个不同的处方,采用湿法制粒法制备骨架片。结果单独使用Eudragit系列产品作辅料,缓释片只能维持6 h的药物持续释放,而RLPO、RSPO与乙基纤维素合用后可以维持12 h的持续释药。结论齐多夫定缓释片与常规片比较,缓释片可以维持12 h的药物持续释放,这样会产生更好的治疗效果,减轻药物的副作用,大大改善患者依存率。更多还原

【Abstract】 Objective To prepare extended-release matrix tablets of zidovudine using hydrophilic Eudragit alone or their combination with hydrophobic ethyl cellulose.Methods Five recipes were determined.Matrix tablets were prepared by wet granulation method.Results The in-vitro drug release study revealed that Eudragit preparation was able to sustain the release only for 6 hours(94%±4.5%),while combining Eudragit with ethyl cellulose could sustain the drug release for 12 hours(88%±4.1%).Conclusion The developed sustained-release tablets of zidovudine have better therapeutic effect than the conventional dosage forms,leading to improved efficacy and better patient compliance.更多还原