【摘要】 目的探索一种测定罗红霉素胶囊含量的简易方法。方法通过茜素红与罗红霉素在适宜的溶液中发生荷移反应,产生红色络合物,采用分光光度法测定络合物吸光值,计算出罗红霉素含量。结果罗红霉素浓度在50.00~200.0μg.mL-1,吸光度(A)与浓度(C)呈良好的线性,A=3.52×10-3C-7.827×10-2,r=0.999 4。回收率为100.6%,(n=9,RSD=1.4%)。结论本方法专属性强,简便、准确、重现性好,可以用于该制剂含量的质量控制。更多还原

【Abstract】 Objective To establish a simple determination method for Roxithromycin capsules.Methods We determined Roxithromycin content with Alizarin charge transfer spectrophotometric method.Based on that,in suitable solution,Alizarin Red and Roxithromycin had charge-transfer reaction,and red complex was calculated.To measure the absorbance or the complex by Spectrophotometric method,we got the content of Roxithromycin.Results The linear range of Roxithromycin was 50.00～200.00 μg·mL-1,A=3.52×10-3 C-7.827×10-2,r=0.999 4,with the average recovery of 100.6%(n=9,RSD=1.4%).Conclusion The method is simple,accurate,sensitive and reproducible,and it may be used in the quality control of Roxithromycin capsules.更多还原