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复方灵芝颗粒中白术挥发油-β-环糊精包合物的制备与表征

Preparation and quality of vaolatile oil-β-cyclodextrin inclusion complex of Atractylodes mqcrocephla in Fufang Lingzhi granules

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【作者】 董英杰张乃先艾莉穆瑛俊

【Author】 DONG Ying-jie1,ZHANG Nai-xian1,AI Li1,MU Ying-jun2(1. Liaoning Institute of Pharmaceutical Industry,Shenyang 110015;2. Shenyang Wanjia Institute of Biological Technology,Shenyang 110015)

【机构】 辽宁省医药工业研究院沈阳市万嘉生物技术研究所 沈阳110015沈阳110015

【摘要】 目的考察复方灵芝颗粒的白术挥发油-β-环糊精包合物的制备与表征。方法采用水溶液搅拌法和研磨法制备,物性鉴定采用红外、热分析、气相、薄层等多种光谱学和色谱学方法。结果2种方法均能得到合格包合物,水溶性和稳定性大大提高,水溶液搅拌法包合物中挥发油含量较高,达到9.47%。结论环糊精包合技术提高了有效组分白术油在颗粒剂中的稳定性。

【Abstract】 Objective To study the preparation and investigate the quality of volatile oil-β-cyclodextrin inclusion complex of Atractylodes macrocephala.Methods Aqueous solution-stirring and mechanical milling were used for the manufacturing,and the physical properties of the inclusion were identified by IR,TA,and TLC.Results The inclusion could be prepared by either of the 2 methods mentioned above.The content of the essential oil of Atractylodes macrocephala of the inclusion complex by aqueous solution stirring was 9.47%.Conclusion The β-cyclodextrin inclusion technology may be used to improve the stability of the volatile oil.

  • 【文献出处】 中南药学 ,Central South Pharmacy , 编辑部邮箱 ,2008年02期
  • 【分类号】TQ461
  • 【被引频次】5
  • 【下载频次】289
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