【摘要】 【目的】研究内蒙古绒山羊毛囊发育兴盛期和休止期BMP2基因在皮肤毛囊中的表达情况。【方法】功能分类基因芯片以及原位杂交技术。【结果】原位杂交结果表明,该基因在休止期毛囊毛干周围高表达,在兴盛期不表达;基因芯片结果显示,同兴盛期相比,休止期BMP2基因在皮肤中表达上调24.65倍。【结论】BMP2基因抑制内蒙古绒山羊皮肤毛囊发育,与维持皮肤毛囊处于休止期有关;该基因主要在皮肤毛囊的毛干周围发挥作用,从而达到维持皮肤毛囊发育处于休止期的作用。更多还原

【Abstract】 【Objective】To explore the expression of BMP2 in the skin and hair follicle in Inner Mongolia cashmere goat in different stages of hair follicle development. Try to explain the mode of action of these genes during the development and cycling of hair follicle【.Method】 GEArray S Series Stem Cell Array(Supper Array)and in situ hybridization were adopted. 【Result】The results show that the expression of BMP2 was up-regulated in the skin in telogen. Whereas it expressed weakly in anagen.【Conclusion】The results indicate that BMP2 mRNA express highly around the hair shaft during the telogen. It may be related to keeping hair follicle in telogen.更多还原