【摘要】 目的:探讨新型抗精神病药物对女性精神分裂症泌乳素、甲状腺激素的影响。方法:选择门诊及住院18~45岁女性精神分裂症(包括分裂样精神病)患者,分为奥氮平组、喹硫平组、阿立哌唑组、利培酮组,每组至少30例。于治疗前、治疗后第4、12周检测泌乳素、甲状腺激素,并记录月经、溢乳等情况。结果:与治疗前相比,奥氮平组及利培酮组患者的血清泌乳素水平升高(分别为P(0.05,P(0.01),并有相应的临床症状;喹硫平组及阿立哌唑组患者的血清泌乳素水平无明显升高。治疗前后四组患者的甲状腺激素水平无明显变化。结论:奥氮平和利培酮均可引起血清泌乳素水平升高,并出现月经延迟、溢乳等症状。喹硫平及阿立哌唑对血清泌乳素无影响。四种药物对甲状腺激素无明显影响。更多还原

【Abstract】 Objective:To study the effects of second generation antipsychotic on the serum prolactin and thyroid hormones levels in female schizophrenia.Methods:Female patients with schizophrenia or schizophrenia-like psychosis by CCMD-3 were randomly allocated to four groups treated with olanzapine,Quetiapine,aripiprazole or risperidone for 12 week.Prolactin and thyroid hormones were measured before and after 4,12 weeks of treatment respectively.Results: Serum prolactin levels increased after the treatment in olanzapine and risperidone groups(P﹤0.05,P﹤0.01)while that in Quetiapine and aripiprazole groups was not.The thyroid hormones had no significant differences after the treatment in four groups.Conclusions: Both olanzapine and risperidone increases the serum prolactin while that Quetiapine and aripiprazole was not.There were no significant changes of thyroid hormones after the four second generation antipsychotic therapy.更多还原