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新型抗精神病药物对女性精神分裂症泌乳素、甲状腺激素的影响
Effects of second generation antipsychotic on prolactin And thyroid hormones in female schizophrenia
【摘要】 目的:探讨新型抗精神病药物对女性精神分裂症泌乳素、甲状腺激素的影响。方法:选择门诊及住院18~45岁女性精神分裂症(包括分裂样精神病)患者,分为奥氮平组、喹硫平组、阿立哌唑组、利培酮组,每组至少30例。于治疗前、治疗后第4、12周检测泌乳素、甲状腺激素,并记录月经、溢乳等情况。结果:与治疗前相比,奥氮平组及利培酮组患者的血清泌乳素水平升高(分别为P(0.05,P(0.01),并有相应的临床症状;喹硫平组及阿立哌唑组患者的血清泌乳素水平无明显升高。治疗前后四组患者的甲状腺激素水平无明显变化。结论:奥氮平和利培酮均可引起血清泌乳素水平升高,并出现月经延迟、溢乳等症状。喹硫平及阿立哌唑对血清泌乳素无影响。四种药物对甲状腺激素无明显影响。
【Abstract】 Objective:To study the effects of second generation antipsychotic on the serum prolactin and thyroid hormones levels in female schizophrenia.Methods:Female patients with schizophrenia or schizophrenia-like psychosis by CCMD-3 were randomly allocated to four groups treated with olanzapine,Quetiapine,aripiprazole or risperidone for 12 week.Prolactin and thyroid hormones were measured before and after 4,12 weeks of treatment respectively.Results: Serum prolactin levels increased after the treatment in olanzapine and risperidone groups(P﹤0.05,P﹤0.01)while that in Quetiapine and aripiprazole groups was not.The thyroid hormones had no significant differences after the treatment in four groups.Conclusions: Both olanzapine and risperidone increases the serum prolactin while that Quetiapine and aripiprazole was not.There were no significant changes of thyroid hormones after the four second generation antipsychotic therapy.
【Key words】 Schizophrenia; Second generation antipsychotic; Prolactin; Thyroid hormones;
- 【文献出处】 中国民康医学 ,Medical Journal of Chinese People’s Health , 编辑部邮箱 ,2008年17期
- 【分类号】R749.3
- 【被引频次】18
- 【下载频次】288