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新型抗精神病药物对女性精神分裂症泌乳素、甲状腺激素的影响

Effects of second generation antipsychotic on prolactin And thyroid hormones in female schizophrenia

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【作者】 曹长安高欢郭金宏廖春平朴胜斌王鹏梁健雄张文顺

【Author】 CAO Chang-an,GAO Huan,GUO Jin-hong,et al(Shenzhen Kangning hospital,Shenzhen 518020,China)

【机构】 深圳市康宁医院

【摘要】 目的:探讨新型抗精神病药物对女性精神分裂症泌乳素、甲状腺激素的影响。方法:选择门诊及住院18~45岁女性精神分裂症(包括分裂样精神病)患者,分为奥氮平组、喹硫平组、阿立哌唑组、利培酮组,每组至少30例。于治疗前、治疗后第4、12周检测泌乳素、甲状腺激素,并记录月经、溢乳等情况。结果:与治疗前相比,奥氮平组及利培酮组患者的血清泌乳素水平升高(分别为P(0.05,P(0.01),并有相应的临床症状;喹硫平组及阿立哌唑组患者的血清泌乳素水平无明显升高。治疗前后四组患者的甲状腺激素水平无明显变化。结论:奥氮平和利培酮均可引起血清泌乳素水平升高,并出现月经延迟、溢乳等症状。喹硫平及阿立哌唑对血清泌乳素无影响。四种药物对甲状腺激素无明显影响。

【Abstract】 Objective:To study the effects of second generation antipsychotic on the serum prolactin and thyroid hormones levels in female schizophrenia.Methods:Female patients with schizophrenia or schizophrenia-like psychosis by CCMD-3 were randomly allocated to four groups treated with olanzapine,Quetiapine,aripiprazole or risperidone for 12 week.Prolactin and thyroid hormones were measured before and after 4,12 weeks of treatment respectively.Results: Serum prolactin levels increased after the treatment in olanzapine and risperidone groups(P﹤0.05,P﹤0.01)while that in Quetiapine and aripiprazole groups was not.The thyroid hormones had no significant differences after the treatment in four groups.Conclusions: Both olanzapine and risperidone increases the serum prolactin while that Quetiapine and aripiprazole was not.There were no significant changes of thyroid hormones after the four second generation antipsychotic therapy.

  • 【文献出处】 中国民康医学 ,Medical Journal of Chinese People’s Health , 编辑部邮箱 ,2008年17期
  • 【分类号】R749.3
  • 【被引频次】18
  • 【下载频次】288
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