【摘要】 目的:检测帕金森病(PD)病人的血清免疫细胞因子的变化,探讨其变化的相关因素。方法:对51例PD病人及35例健康志愿者应用放射免疫法分别检测其血清IL-1β、IL-2、IL-6和TNF-α水平。结果:PD组血清IL-1β、IL-6和TNF-α的水平明显高于对照组(P<0.01),IL-2无差异。4项细胞因子变化明显的是IL-6和TNF-α,与变化相关的因素是年龄、病程和服用L-多巴的剂量。高龄、长病程和服用L-多巴用量≥410mg/d者,其IL-6和TNF-浕水平显著增高(P<0.05~0.01),而性别、病情和辅加服用DA受体激动剂与细胞因子水平变化均无相关性。结论:PD病人的高龄、长病程、加之长期大量服用神经递质药物L-多巴可能是导致患者免疫功能紊乱的主要直接因素,而与PD本身无因果关系。更多还原

【Abstract】 Objective:To detect the level of immune related cytokines in the serum of the patient with Parkinson’s Disease (PD) and to explore the influencing factors of the cytokines.Methods:51 patients with PD (PD group) and 35 healthy control (control group) were studied.The two groups were detected the serum concentration of IL-1β,IL-2,IL-6 and TNF-α by the way of radio immunity.Results:The serum level of IL-6 and TNF-α in the PD group is significantly higher than that of the control group (P<0.01).The serum level of IL-1β in the PD group is significantly higher than that of the control group (P<0.05).However,there is no difference in IL-2 between the two groups.The influencing factors of the difference on IL-6 and TNF-α between the two groups are age,the duration of illness and the dose of L-dopa.The old age,the long duration of illness and intake L-dopa more than 410mg/d may lead the level of IL-6 and TNF-α significantly increased(P<0.05～0.01).However,the gender,the state of illness and admit the agonist of dopa receptor can not interfere the serum level of IL-6 and TNF-α.Conclusion:The old age,the long duration of illness and the high dose of L-dopa maybe the key factors that lead to the disturbance of immunologic function in the patient with PD.It is not PD itself caused the disturbance of immunologic function directly.更多还原