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人参水提物对阿霉素所致大鼠心肌损伤的影响

Effect of Water Extracts from Ginseng on Myocardium Injury Induced by ADR in Rats

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【作者】 洪建跃赵不非赵福弟

【Author】 HONG Jian-yue1,ZHAO Bu-fei2,ZHAO Fu-di1(1.Basic Medical College of Beihua University,Jilin 132013,China;2.Affiliated Hospital of Beihua University,Jilin 132011,China)

【机构】 北华大学基础医学院北华大学附属医院北华大学基础医学院 吉林吉林132013吉林吉林132011吉林吉林132013

【摘要】 目的探讨人参水提物对阿霉素所致心脏损伤的保护作用.方法50只Wistar大鼠随机分3组:对照组(NS组,10只)、阿霉素组(ADR组,20只)、阿霉素+人参水提物组(ADR+G,20只).13 d后在光镜下观察心肌细胞病理形态学变化,检测心肌ATP含量.结果光镜下ADR+G组心肌损害程度较ADR组轻,ADR+G组心肌ATP含量明显高于ADR组(P<0.01).结论人参水提物对阿霉素所致大鼠心肌损伤有明显的保护作用.

【Abstract】 Objective To study the protective effects of water extracts from Ginseng on myocardium injury caused by adriamycin(ADR) in rats.Methods Fifty Wistar rats were randomly divided into three groups:control group,ADR group and ADR+G group.ATP in the sera and myocardium were detected and the histopathological study was performed under light microscope.Results The extent of the myocardial injury in ADM+G group was not as significant as that in the ADR group.ATP in the sera and myocardium in ADR+G group were significantly higher than that of ADR group((P<)(0.01)).Conclusion The water extracts from Ginseng has obvious protective effects on myocardial injury caused by ADR in rats.

  • 【文献出处】 北华大学学报(自然科学版) ,Journal of Beihua University(Natural Science) , 编辑部邮箱 ,2008年02期
  • 【分类号】R285
  • 【被引频次】7
  • 【下载频次】171
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