【摘要】 目的:探讨局部5-氨基酮戊酸光动力学疗法(ALA-PDT)治疗老年疣病的疗效。方法:93例老年疣患者,分别采用局部ALA-PDT治疗63例(A组),二氧化碳(CO2)激光治疗30例(B组)。结果:A组患者经3次治疗后,痊愈16例(25.4%),显效25例(39.7%),有效13例(20.6%),无效9例(14.3%),总有效率65.1%,复发率6.3%,术后伤口疼痛3.2%,无其它明显副作用发生;B组治疗1次,痊愈率100%,复发率16.7%;伤口并发感染7例(23.3%),愈后局部遗留浅表瘢痕9例(30%),伤口疼痛100%。B组复发率、伤口感染率及局部遗留瘢痕的发生率均显著高于A组(P<0.05)。结论:ALA-PDT无明显痛苦、无瘢痕形成,且复发率低,适合于头面部多发性、较大面积的皮损。更多还原

【Abstract】 Objective:To investigate the effects of 5-aminolaevulinic acid-photodynamic therapy(ALA-PDT) in the treatment of senile warts.Methods:Sixty-three patients with senile warts were treated by ALA-PDT and other 30 cases by CO2 laser as control group.Results:All patients were treated 1-3 times in ALA-PDT group,and the number of cases treated 1,2 and 3 times was 45(71.4%),15(23.8%) and 3(4.8%),respectively.Sixteen cases(16/63,25.4%) were cured,25 cases(39.7%) obtained significant improvement,13 cases(20.6%) moderate improvement,and 9 cases(14.3%) had no change or mild improvement.The total effective rate was 65.1%,recurrent rate was 6.3%,and postoperative wound pain occurred in 3.2% patients.In control group,all patients were cured,recurrent rate was 16.7%,7 cases(23.3%) had postoperative wound infection,9 cases(30%) had scar and 100% patients had wound pain.The recurrent rate,incidence of wound infection and the occurrence of local scar in control group were significantly higher than in ALA-PDT group(P<0.05).Conclusion:Local ALA-PDT is a simple,effective and new treatment with lower recurrent rate,no scar formation and excellent cosmetic results for senile warts, especially for the large and multifocal lesions located on the face.更多还原