【摘要】 目的观察泮托拉唑与格拉司琼+地塞米松联用治疗肿瘤化疗所致消化道反应的疗效和不良反应。方法将125例化疗所致难治性呕吐的病人随机分为两组,在下一周期化疗中泮托拉唑组予泮托拉唑+格拉司琼+地塞米松,对照组予格拉司琼+地塞米松,比较两组的临床效果与药物不良反应。结果泮托拉唑组在预防食欲不振、抑制恶心、呕吐等方面明显优于对照组,差异有统计学意义(P值均<0.05);两组头晕、腹痛、便秘、乏力、颜面潮红、失眠等不良反应发生率相仿,差异无统计学意义(P值均>0.05)。结论泮托拉唑联合格拉司琼防治化疗药物所致消化道反应疗效较好,值得临床推广应用。更多还原

【Abstract】 Objective To investigate the curative and adverse effects of pantoprazole combined with granisetron for alimentary toxicities caused by tumor chemotherapy.Methods One hundred and twenty-five cases involved in intractable vomiting caused by tumor chemotherapy were divided into two groups at random on the second chemotherapy cycle. Sixty-four patients of pantoprazole group were treated with pantoprazole +granisetron+dexathasone ,and sixty-one ones of control group were treated with granisetron+dexathasone.Results Pantoprazole group was superior to control group in the prevention of appetite loss, nausea and vomiting with significant difference (P<0.05).Side-effects such as headache, stomachache, constipation, acratia, blushing, insomnia were similar(P>0.05).Conclusion Pantoprazole combined with granisetron is a good choice in prevention of alimentary toxicities caused by tumor chemotherapy and worth extending its clinical application.更多还原