【摘要】 目的:探讨首发重性抑郁症患者是否存在大脑结构形态学的改变。方法:对20例首发、未服药重性抑郁症患者和20例年龄、性别等相匹配对照组进行全脑MRI检查。结果:重性抑郁症患者组前额叶、左右颞叶及小脑、双侧海马及前扣带回灰质密度显著降低,左侧杏仁核灰质密度增加。结论:首发重性抑郁症患者前额叶、颞叶、小脑、前扣带回、海马杏仁核有灰质密度改变,可能是重型抑郁症患者病理性变化的脑结构基础。更多还原

【Abstract】 Objective:To investigate the possible changes of brain structural morphometry in patients with first episode of major depression(MD).Methods:Brain structural images of twenty MDs and twenty age-and-education-matched healthy comparison participants(HC), including T1 and 3D images gained by magnetic resonance imaging scan.Results:In comparison with controls, the MDs had significantly lower density of the prefrontal cortex, bilateral temporal lobe, bilateral hippocampus, cerebellum and anterior cingulate cortex(P<0.005).But MDs had significantly higher density of left amygdala(P<0.005).Conclusion:The results suggest that there may be morphometric and pathophysiologic changes in brain areas, including prefrontal cortex, bilateral temporal lobe, bilateral hippocampus, cerebellum, anterior cingulate cortex and left amygdala in the patients with MD.更多还原