【摘要】 目的:利用功能磁共振成像(fMRI)和局部一致性(regional homogeneity,ReHo)方法探测精神分裂症患者在静息状态下是否存在脑功能异常。方法:对18例精神分裂症患者和18例正常对照进行静息状态的fMRI检查,应用ReHo方法处理fMRI数据。结果:与正常人相比,精神分裂症患者静息状态下脑的BOLD信号的ReHo普遍降低(P<0.05)。ReHo降低的脑区有双侧额叶内侧回、颞上回、颞下回、枕中回、枕下回和小脑后叶;左侧扣带回前部、海马回、颞中回、中央后回和脑桥;右侧额上回、顶上小叶、楔前叶、中央旁小叶、中央前回和小脑蚓部。结论:精神分裂症患者在静息状态下即可能存在脑功能异常,ReHo可能有助于精神分裂症静息状态的理解。更多还原

【Abstract】 Objective: To explore whether abnormal brain activity exists in schizophrenics during resting state by fMRI technique and regional homogeneity(ReHo)approach. Methods: fMRI images were obtained in resting state from 18 patients with schizophrenia diagnosed with the DSM-Ⅳ criteria and 18 control subjects. The newly published ReHo approach was applied for fMRI data analysis. Results: Patients with schizophrenia showed decreased ReHo of BOLD signal in resting brain compared with control subjects(P<0.05). The decreased ReHo was distributed over bilateral medial frontal, superior and inferior temporal, middle and inferior occipital gyrus and cerebellar posterior lobe; the left hemespheric orbital frontal, anterior cingulate, parahippocampal, middle temporal, postcentral gyrus and pons in brainstem; the right hemespheric rectus gyrus, superior parietal lobule, precuneus, paracentral lobule, precentral gyrus and cerebellar vermis. Conclusion: The resting state fMRI study showed that abnormal brain activity of schizophrenia might exist in resting state. The ReHo may be potentially helpful in exploring resting state of schizophrenia.更多还原