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若干蛇毒蛋白的结构生物学研究
Structural biology of some snake venom protein families
【摘要】 以本研究组较有研究特色的五种蛇毒蛋白家族为线索,简要综述了蛇毒金属蛋白酶、蛇毒丝氨酸蛋白酶、蛇毒crisp蛋白、蛇毒磷脂酶A2及蛇毒神经毒素等蛋白家族有关结构生物学研究的结果、现状及进展.强调了蛇毒蛋白研究中蛇毒糖蛋白的结构生物学研究、超高分辨率晶体学研究及与蛇毒蛋白相关的复合物结构生物学研究的重要性.
【Abstract】 Following the clues from our group’s characteristic investigations of five snake venom protein families,a short review was provided on some research conclusions,current opinions and latest advances from structural biology of snake venom protein families of serine proteases,metalloproteinase,CRISP,phospholipase A2 and neurotoxin as well.This review emphasized the importance of structural biology of snake venom glycoproteins,crystal structures at an ultrahigh resolution and the complex structure related to snake venom proteins in the field of snake venom proteins.
【Key words】 snake venom； crystal structure； metalloproteinase； serine protease； Phospholipase； Cysteine-rich secretory protein； neurotoxin； ultra-high resolution；
- 【文献出处】 中国科学技术大学学报 ,Journal of University of Science and Technology of China , 编辑部邮箱 ,2008年08期
- 【分类号】R99
- 【被引频次】15
- 【下载频次】776