【摘要】 以单克隆抗体研究为例,从一个侧面介绍了生物技术及药物研究在中国科学技术大学的发展.先后研制过多种单克隆抗体.其中,用人α干扰素单克隆抗体制备的人α干扰素单克隆抗体亲和胶,成功地应用于干扰素的工业生产,解决了国内干扰素生产中的关键技术问题,并依此技术成立了安徽省第一家具有自主研发生物技术药物产品的生物技术公司;肿瘤抗原p185erbB-2/HER-2单克隆抗体有一种已被开发成肿瘤蛋白免疫组化诊断试剂,于2004年获得国家新药证书,现已转化为产品,另一种同类单抗正在用于抗体治疗药物的研发.此外,基于蛇毒抗栓组分的研究成果,与香港兆峰集团合资成立了兆峰科大药业公司,研发的蛇毒溶栓素已获得国家一类新药证书.今后更多的研发成果将在生物技术医药产业中得到应用.更多还原

【Abstract】 As an example of R & D of Biotechnology and Drugs at USTC,several monoclonal antibodies(Abs) have been prepared for applications in industrial and medicinal applications.The Ab against human α-interferon(IFN) was used to prepare the IFN affinity chromatography gel which can provide efficient means for the manufacture of IFNs.It made this key technique for manufacturing IFNs no longer rely on input.Based on these,Anhui Anke High Biotechnology INC was founded in 1995.One of the Abs against oncoprotein p185erbB-2/HER-2 was developed for the diagnostic reagent of the cancers overexpressing oncoprotein p185 such as breast cancer and ovary cancer.This diagnostic reagent was proved by SFDA in 2004.Another Ab against p185 which can inhibit growth and proliferation of cancers overexpressing p185 is being developed into a therapeutic antibody drug.In addition,the fragments with anti-platelet aggregation activities have been developed for a potential anti-thrombus drug by a pharmaceutical company based on the research of the LAbs in our school.More achievements are being made at USTC and will be applyied to biotech industries.更多还原