【摘要】 目的探讨人类DNA修复基因XRCC3-241单核苷酸多态性(SNP)与非小细胞性肺癌的发生关系。方法103例非小细胞性肺癌患者(经病理检查证实)作为病例组,139例健康体检者作为对照组,采外周血。XRCC3-241基因分型检测采用Taqman探针PCR法,分析病例组和对照组的XRCC3-241的SNP。结果在139例健康体检者中,118例为C/C基因型,占总数的84.9%,21例为C/T基因型,占总数的15.1%。在103例非小细胞性肺癌患者中,91例为C/C基因型,占总数的88.3%,12例为C/T基因型,占总数的11.6%。病例组和对照组均未检测到T/T基因型。结果表明,携带T/C基因型的人患非小细胞性肺癌的风险性是C/C基因型的1.004倍(P>0.05)。非小细胞性肺癌组吸烟个体的比例(68.9%)明显高于对照组(36.7%);吸烟可显著增加肺癌的发病风险(P<0.01)。结论XRCC3-241 SNP与非小细胞性肺癌发生的风险无相关性;吸烟显著增加非小细胞性肺癌的发病风险。更多还原

【Abstract】 Objective To investigate the association of single nucleotide polymorphism(SNP) of XRCC3-241 gene with the development of non-small cell lung cancer(NSCLC).Methods XRCC3-241 genotype was determined by Taqman SNP genotyping assays in 103 patients with non-small cell lung cancer and 139 matched controls recruited by matching on living area,sex and age.Results In NSCLC patients the frequency of genotype C/C and C/T was 84.9%(118/139) and 15.1%(21/139),respectively.In healthy controls the frequency of genotype C/C and C/T were 88.3%(91/103) and 11.6%(12/103),respectively.The risk of genotype T/C for NSCLC was 1.004 over genotype C/C.(P>0.05).Conclusion The XRCC3-241 SNP was not associated with the non-small cell lung cancer development.更多还原