【摘要】 目的观察血浆脑钠素(BNP)水平与急性心肌梗死(AMI)范围、左室功能及预后的关系。方法63例确诊为AMI的患者,入院后进行常规检查且24h后测血浆脑钠素浓度,其中,62例患者行PCI,1例行CABG治疗。1周后检查超声心动图测定左室射血分数(LVEF),所有患者随访3个月,观察血浆BNP浓度与AMI的范围、左室功能及预后的关系。结果血浆BNP水平与AMI面积呈正相关(P<0.01),与LVEF呈负相关(P<0.05),且血浆BNP高的患者心血管事件发生率高(P<0.05),均有统计学意义。结论血浆BNP浓度反映了AMI的严重程度;AMI范围越大,左室功能越差,脑钠素的水平越高,且脑钠素可作为心血管事件的预测指标。更多还原

【Abstract】 Objective To study the relationship of the plasma concentration of brain natriuretic peptide (BNP) with severity, left ventricular function, prognosis in the patients with acute myocardial infarction(AMI).Methods 63 patients with AMI were enrolled in this clinical investigation. The plasma concentrations of BNP were measured at 24 hours after the infarction. According to the electrocardiogram, the infarction areas were measured. Left ventricular function was evaluated by echocardiography with the parameters of left ventricular ejection fraction (LVEF) after one week. Patients were followed up for three months, relationship of plasma concentration of BNP with infarction areas, left ventricular function and prognosis in the patients of AMI were observed. Results The concentration of BNP in the patients with AMI was related to severity of the disease. With enlargement of infarction areas, the BNP increased (P<0.01) .With the decrease of LVEF, the BNP increased (P<0.05) .The clinical cardiac events occurred more frequently in the patients with a higher BNP(P<0.05). Conclusion Plasma concentration of BNP in patient with AMI might be a reliable biochemical marker which can objectively evaluate the degree and prognosis of this disease.更多还原