【摘要】 目的探讨常用肝功能指标判断汉坦病毒所致肝损害的临床价值。方法回顾性分析367例肾综合征出血热(HFRS)患者肝功能指标、病情及治疗结局的关系。结果HFRS患者ALT、AST、TBIL及白蛋白异常分别占73.84%(271/367)、79.84%(293/367)、13.35%(49/367)和44.41%(163/367)。HFRS不同临床型间ALT、AST和TBIL差异有统计学意义(P<0.001),而白蛋白各型间差异无统计学意义(P>0.05)。结论汉坦病毒易于引起肝脏损害,肝损害程度与病情、预后有关;ALT、AST及TBIL是反映肝脏损害程度的重要指标;而白蛋白不能作为汉坦病毒肝损害程度的判断指标。更多还原

【Abstract】 Objective To evaluate clinical usefulness of liver function indicators for determination of hepatic injury caused by Hantavirus. Methods A retrospective analysis was performed on relationship of liver function indicators, clinical situation and prognosis of 367 patients with hemorrhagic fever with renal syndrome (HFRS). Results The abnormity rates of ALT, AST, TBIL and ALB were 73.84%, 79.84%, 13.35% and 44.41%, respectively. Analysis of variance showed that all indicators of ALT, AST and TBIL had high significant difference (P<0.001) among mild, moderate, severe and gravis types. Conclusion Hantavirus infection frequently causes hepatic injury, which is in concordance with severity and prognosis of HFRS. The levels of ALT, AST and TBIL are sensitive indicators for evaluation of hepatic injury caused by hantavirus, while sea albumin is not.更多还原