【摘要】 目的观察开普拓、5-氟尿嘧啶、亚叶酸钙时辰化疗治疗大肠癌肝转移临床疗效及毒副作用。方法大肠癌手术后肝转移患者28例,随机分为A、B两组进行化疗,方案为:开普拓、5-氟尿嘧啶、亚叶酸钙,A组按时辰给药法治疗,B组按常规给药法治疗,按WHO标准观察两组患者的近期疗效及不良反应。结果A组有效率(CR+PR)为78.5%,B组为35.7%,A组与B组相比较差异有显著性意义(P<0.01),A组对化疗药物的毒副反应均较B组轻,A、B两组Ⅲ/Ⅳ度中性粒细胞减少、腹泻、脱发的发生率相比较差异均有显著性意义(P<0.05)。结论开普拓、5-氟尿嘧啶、亚叶酸钙时辰化疗作为一种新的给药方式进行大肠癌肝转移化疗,具有较好的临床疗效及较低的毒副反应。更多还原

【Abstract】 Objective To evaluate the clinical efficacy and the adverse drug reactions of chronomodulated chemotherapy of irinotecan(CPT-11) combined with 5-fluorouracil(5-FU) and calcium folinate(CF) on colorectal carcinoma patients with hepatic metastasis.Methods 28 colorectal carcinoma patients with hepatic metastasis were divided into group A and B.group A were employed the chronomodulated chemotherapy of CPT-11 combined with 5-FU and CF procedure,while group B used the CPT-11combined with 5-FU and CF rountinly.The short term efficacy and adverse drug reactions were evaluated according to the standard by WHO.Results The higher percentages of clinical efficacy clinical efficacy(CR + PR) was A,78.5% vs B,35.7% and the lower percentages of adverse drug reactions occurred in group A(P<0.05) .Conclusion Chronomodulated chemotherapy of CPT-11 combined with 5-FU and CF may be more effective and may cause the lower adverse drug reactions on colorectal carcinoma with hepatic metastasis.更多还原