【摘要】 以生物可降解的乙交酯-丙交酯共聚物(PLGA)为载体,用溶剂法制备了地塞米松眼部植入剂。考察了处方中PLGA的构成和重均分子量、药物含量及释放调节剂对植入剂体外释放的影响。结果表明用分子量较小、乙交酯和丙交酯的摩尔比为50:50的PLGA制备的植入剂体外释药较快;提高药物含量、选用亲水性调节剂或乳酸也能加快体外释放。更多还原

【Abstract】 The ocular implant loaded with dexamethasone was prepared by solvent method with the biodegradable polymer,polylactic-co-glycolic acid (PLGA) as carriers.The in vitro release was affected by the weight- average molecular weight and monomer ratio LA/GA of PLGA,the drug loading and other excipients in the formulation. The results demonstrated that the in vitro release velocity was faster when the implant was prepared by PLGA with the lower weight-average molecular weight and LA/GA of 50:50,addition ofhydrophilic excipients or lactic acid.更多还原