【摘要】 [目的]探讨肺癌患者胸水中肿瘤标志物的检测在临床上的应用价值。[方法]应用酶联免疫吸附实验(ELISA)检测170例肺癌患者和58例肺部良性疾病患者胸水中神经元特异性烯醇化酶(NSE)、胃泌素释放肽前体(pro-GRP)、细胞角蛋白19(CYFRA21-1)、鳞癌抗原(SCC)、p53抗体和CA199的水平含量。[结果]肺癌患者胸水的6种肿瘤标志物水平均明显高于肺部良性疾病组,差异有统计学意义(P<0.01)。NSE、pro-GRP在小细胞肺癌中的水平明显高于其他类型的肺癌(P<0.01);CYFRA21-1、鳞癌抗原(SCC)在鳞癌中的水平明显高于其他类型的肺癌(P<0.01)。[结论]胸水中6种肿瘤标志物对于肺癌的辅助诊断有一定的临床意义。更多还原

【Abstract】 [Purpose] To investigate the clinical significance of tumor markers in pleural effusion in the patient with lung cancer. [Methods] The level of NSE,pro-GRP,CYFRA21-1,SCC,p53 antibody and CA199 in pleural effusion of 170 patients with lung cancer and 58 patients with benign lung lesion were detected by ELISA. [Results] The level of the six tumor markers in patients with lung cancer was higher than that of patients with benign lung lesion (P<0.01).The level of NSE,pro-GRP in patients with small cell lung cancer was higher than that of other subtypes of the lung cancer(P<0.01). The level of the CYFRA21-1,SCC in patients with squamous carcinoma was higher than that of other subtypes of the lung cancer(P<0.01). [Conclusion] Six tumor markers in pleural effusion have a clinical significance for assistant diagnosing lung cancer.更多还原