Efficacy and Safety of Transdermal Fentanyl(TDF)in Treatment of Pain Caused by Interventional Embolization Therapy

【摘要】 <正>Objective:Interventional embolization therapy is well accepted in cancer treatment,but patient may suffer from a moderate-to-severe pain after therapy and its quality of life(QoL)is influenced,this study is to observe the efficacy and safety of transdermal fentanyl(TDF)in the management of pain caused by interventional embolization therapy.Methods:Morphine 10rag and TDF 25μg/h were immediately used in 52 patients who had moderate-to-severe pain complicated by interventional embolization therapy,the pain intensity was evaluated by visual analogue scale(VAS).If VAS≥4 at 12 h after treatment,the dosage of TDF added into 50μg/h.At Oh,12h,24h,72h,1 week,2 weeks after TD,the vas and adverse events were observed respectively.Result:There was an obvious decrease in VAS at 12h after TDF treatment in the patients of which only 9 patients used 50ug/h dosage after partial splenic embolization(PSE)therapy.Most patients got satisfactory pain relief both the TDF 25μg/h and TDF 50μg/h group(VAS 0-1).The adverse events were nausea,vomiting and dizzy,especially in the TDF 50μg/h group.No respiratory depression was observed and only one patient got retention of urine.Conclusion:TDF was effective and safe in the treatment of moderate-to-severe pain after interventional embolization therapy.更多还原

【Abstract】 Objective:Interventional embolization therapy is well accepted in cancer treatment,but patient may suffer from a moderate-to-severe pain after therapy and its quality of life(QoL)is influenced,this study is to observe the efficacy and safety of transdermal fentanyl(TDF)in the management of pain caused by interventional embolization therapy.Methods:Morphine 10rag and TDF 25μg/h were immediately used in 52 patients who had moderate-to-severe pain complicated by interventional embolization therapy,the pain intensity was evaluated by visual analogue scale(VAS).If VAS≥4 at 12 h after treatment,the dosage of TDF added into 50μg/h.At Oh,12h,24h,72h,1 week,2 weeks after TD,the vas and adverse events were observed respectively.Result:There was an obvious decrease in VAS at 12h after TDF treatment in the patients of which only 9 patients used 50ug/h dosage after partial splenic embolization(PSE)therapy.Most patients got satisfactory pain relief both the TDF 25μg/h and TDF 50μg/h group(VAS 0-1).The adverse events were nausea,vomiting and dizzy,especially in the TDF 50μg/h group.No respiratory depression was observed and only one patient got retention of urine.Conclusion:TDF was effective and safe in the treatment of moderate-to-severe pain after interventional embolization therapy.更多还原