【摘要】 目的:研究远志的抗抑郁活性成分。方法:用色谱法分离远志的化学成分,根据波谱学分析鉴定了化合物的结构,用MTT法评价其细胞毒活性。结果从远志分离得到8个化合物,分别鉴定为:西伯利亚远志糖A1(sibiricose A1,1),西伯利亚远志糖A5(sibiricose A5,2),tenuifoliside A(3),西伯利亚远志糖A6(sibiricose A6,4),3,4,5-三甲氧基肉桂酸甲酯(3,4,5-trimethoxycinnamate,5),远志酮Ⅲ(polygalaxanthoneⅢ,6),tenuifolioses A(7),tenuifolioses H(8)。结论:化合物1为首次从远志中分离得到,远志中的寡糖酯类成分对谷氨酸造成的PC12细胞损伤均有一定的保护作用。更多还原

【Abstract】 Objective: To investigate the antidepressant components of Polygala tenuifolia.Method: The chromatographic method was used to isolate and purify the chemical constituents,their structures were identified by spectral analysis,MTT method was applied to investigate their cytotoxic activities.Result: Nine compounds were isolated from the roots of P.tenuifolia.Their structures were identified as sibiricose A1(1),sibiricose A5(2),tenuifoliside A(3) and 3′,6-disinapoyl sucrose(4),sibiricose A6(5),3,4,5-trimethoxycinnamate(6),polygalaxanthone Ⅲ(7),tenuifolioses A(8),tenuifolioses H(9) and some compounds’ activities to PC12 were observed.Conclusion: Compound1 was isolated from this plant for the first time.Compounds 2,3 could protect PC12 cells damage induced by P.tenuifolia.更多还原