【摘要】 目的探讨青年人腰椎BMD和SD正常参考值影响骨质疏松症(OP)检出率的程度。方法用GE-Lunar公司的DXA仪测量骨密度,调查全国6个中心11418例腰椎PA和髋部BMD,建立了骨密度参考数据库。6个中心的仪器内部精度0.3%~0.7%,仪器间的精度1.1%。从T-score=(受试者BMD-青年人平均BMD)÷青年人骨密度SD值公式中可知,OP检出率与青年人平均BMD呈正比与SD值呈反比。结果用6个中心及总体各自的青年人平均BMD和SD值为参考标准,对同一人群计算T-score和获得的OP检出率则不相同;发现青年人平均BMD每变化0.01g/cm2,则OP检出率变化1.6%(呈正相关),其SD值每变化0.01g/cm2,则OP检出率变化4%(呈负相关)。结论青年人平均BMD和SD值不同引起OP检出率也不相同。为了让不同中心的OP检出率有可比性,建议同一个类型的BMD仪,同一个种族,同一个地区用一个设计较完善大样本的参考数据库,以其青年人正常参考值计算T-score。更多还原

【Abstract】 Objective To explore the effect of different lumbar BMD and standard deviation (SD) of the young people to the detective rate of osteoporosis. Methods We measured BMD of 11418 in lumbar (PA) and hip in 6 centers in China by DXA made in GE-Lunar, and we established the BMD referent database. The precisions of inner machine were 0.3%～0.7%, and the precision of different machine was 1.1%. From the formula T-score=(individual BMD-the young BMD)/the standard deviation of the young we could understand that the detective rate of osteoporosis was direct ratio to the BMD of the young and inverse ratio to the standard deviation. Results There were different BMD and the standard deviation in 6 centers and in total. There were different T-score and detective rate of osteoporosis by referencing different BMD and SD in the same group. We also found that the detective rate changed 1.6% with BMD of the young changed 0.01 g/cm2 (positive correlation), and the detective rate of osteoporosis changed 4% with SD changed 0.01 g/cm2 (negative correlation). Conclusion Changing the BMD and SD of the young could induce the detective rate of osteoporosis changing and irrelevant to the individual BMD. In order to have comparability of the detective rate of osteoporosis in different centers, we suggested establishing reference data of same race, same area and same machine. T-score was calculated with the normal BMD and SD of the young.更多还原