【摘要】 目的:探讨子宫内膜透明细胞癌的临床特点、治疗和预后。方法:系统回顾自1997年1月～2006年12月收治的48例子宫内膜透明细胞癌和同期子宫内膜样腺癌601例患者的临床资料。结果:48例子宫内膜透明细胞癌和同期601例子宫内膜样腺癌的平均年龄分别为54.1岁和51.7岁,两者相比较,差异有显著性(P<0.05)。子宫内膜透明细胞癌盆腔淋巴结转移率、脉管转移率、肌层浸润率均高于子宫内膜样腺癌,差异有显著性,(P<0.05),48例子宫内膜透明细胞癌均手术治疗,术后未辅助治疗10例,辅助化疗14例,辅助放疗13例,术后孕激素治疗2例,化疗联合放疗6例,化疗联合孕激素治疗1例,放疗联合孕激素治疗2例。结论:子宫内膜透明细胞癌在子宫内膜癌的发病率较低,年龄较子宫内膜样腺癌大,易发生早期转移,预后较差。治疗宜采取全面的分期手术联合放化疗。更多还原

【Abstract】 Objective: To investigate the clinical features, management, and prognosis of endometrium clear cell carcinoma. Methods: A total of 48 cases of endometrium clear cell carcinoma and 601 cases of endometrioid adenocarcinoma seen in our hospital from January 1997 to December 2006 were analyzed retrospectively. Results: The mean age of the patients with endometrium clear cell carcinoma and patients with endometrioid adenocarcinoma was 54.1 years and 51.7 years, respectively, with a significant difference(P<0.05). Compared with the endometrioid adenocarcinoma, endometrium clear cell carcinoma presented with higher metastasis rate of pelvis lymphoid node and vessel and infiltrate rate of muscular layer(P<0.05). These 48 cases of endometrium clear cell carcinoma all underwent surgery. After surgery, 14 patients had chemotherapy, 13 patients had radiation therapy(RT), two patients had hormone therapy, six patients had a combination of RT and chemotherapy, one patient had a combination of chemotherapy and hormone therapy, two patients had a combination of RT and hormone therapy, and 10 patients didn’t receive any adjuvant therapies. Conclusion: Endometrium clear cell carcinoma comprises a small percentage of endometrial cancers. The onset age is higher than that of endometrioid adenocarcinoma. It has been shown to be associated with high metastasis rate and poor survival. Patients with endometrium clear cell carcinoma should be treated with complete staging surgery and combination of regional RT and chemotherapy.更多还原