【摘要】 目的:探讨养血调肝方对去卵巢大鼠模型骨密度及骨代谢方面的影响。方法:将雌性6月龄健康wistar大鼠70只随机分为假手术组、模型组、尼尔雌醇组、六味地黄丸组、养血调肝方大、中、小剂量组。用药4个月后检测各组大鼠骨密度、骨矿含量及血清骨钙素、碱性磷酸酶、抗酒石酸酸性磷酸酶、尿脱氧吡啶酚。结果:养血调肝方能明显地增加去卵巢后大鼠骨密度、骨矿含量;升高去卵巢大鼠血清骨钙素、碱性磷酸酶水平,或降低血清抗酒石酸酸性磷酸酶和尿脱氧吡啶酚水平。结论:养血调肝方能通过促进骨形成或抑制骨吸收增加骨密度、骨矿含量,从而对绝经后骨质疏松症有一定的防治作用。更多还原

【Abstract】 Objective:To evaluate the effect of Yangxue Tiaogan Formula(YTF) on bone mineral density(BMD) and bone metabolism in ovariectomized rats.Methods:Seventy 6-month-old female Wistar rats were randomly divided into 2 groups:the model of postmenopausal osteoporosis(PMOP) group established by removing their ovaries and the sham model group.Meanwhile,the rats in PMOP group were randomly divided into 6 groups:the model group,the nilestriol group,the Liuwei Dihuang Pill(LDP) group,the high-dose group,the middle-dose group and the low-dose group of YTF.After 4 months of treatment with different drugs,the contents of BMD,bone mineral content(BMC),serum osteocalcin,AKP,TRAP and deoxypyridinoline(D-Pyd) were detected.Results:Compared with the model group,the contents of BMD and BMC were remarkably increased,the levels of serum osteocalcin and AKP were raised and the levels of TRAP and D-Pyd were reduced in YTF groups.Conclusion:YTF can prevent and treat PMOP by way of promoting bone formation or inhibiting bone resorption in the ovariectomized rats.更多还原