【摘要】 目的:制备酒石酸美托洛尔缓释骨架片。方法:采用亲水性高分子材料HPMC为骨架,制备酒石酸美托洛尔缓释片,采用正交试验法以药物体外释药百分率为指标优选制剂处方。结果:最佳处方为30%HPMC K4M作阻滞剂、淀粉和乳糖(1∶1)为填充剂,10%PVP乙醇液为黏合剂,1%硬脂酸镁为润滑剂,采用湿法制粒,压片。结论:本品制备工艺简便,药物体外释放符合Higuchi模型,自制缓释骨架片较市售缓释片具有更好的缓释效果,能维持药物12h内缓慢释放。更多还原

【Abstract】 OBJECTIVE To prepare metoprolol tartrate sustained-release matrix tablets.METHODS This tablets were prepared by the water-soluble HPMC(K4M) matrix,and using release rate of drug as marker,the formulation was optimized by the orthogonal design test.RESULTS The optimal formulation was as follow: using 30% HPMC K4M as retardants,starch and lactose(1∶1) as fillers,10% PVP ethanol as adhesives,and 1% magnesium stearate as lubricants.Sustained-release tablets were prepared by the wet granule compression technique.CONCLUSION This preparation technology was simple.The release in vitro of this drug accorded with Higuchi equation and sustaining within 12 h,and showed preferable sustained-release effect compared with marke sustained-release tablets.更多还原