【摘要】 目的:制备高稳定性的萘普生微乳,考察萘普生微乳对离体小鼠皮的透皮能力。方法:通过原子力扫描探针显微镜、ζ-电位粒度仪测定萘普生微乳的粒度及其分布。用稳定性实验考察萘普生微乳的稳定性。用改进的Franz扩散池研究萘普生微乳的透皮速率。高效液相色谱法测定萘普生的含量。结果:1%萘普生的微乳液滴的平均粒径为(48.6±1.8)nm,萘普生的平均透皮速率为(115.06±9.87)μg.cm-2.h-1,透皮吸收行为符合Fick′s第一定律。结论:萘普生微乳能够显著促进萘普生的透皮吸收。更多还原

【Abstract】 OBJECTIVE To prepare O/W microemulsion formulasion containing naproxen and investigate its in vitro transdermal delivery ability.METHODS The microemulsion was prepared and characterized using atomic force microscope and zetasizer analysis instrument.The permeation flux of naproxen was determined in vitro using Franz diffusion cell.The content of naproxen was measured by HPLC.The stability tests were performed to evaluate thenaproxen microemulsion.RESULTS The average droplet size of microemulsion containing 1%naproxen was(48.6±1.8)nm.The permeation rate of(115.06±9.87)μg·cm-2·h-1 was showed in vitro.The permeation of the microemulsion was described by the Fick’s frist diffustion law.CONCLUSION These results indicates that the studied miroemulsion system could improve the transdermal absorption of naproxen.更多还原