【摘要】 目的:探讨酚妥拉明对新生儿持续肺动脉高压(PPHN)的治疗效果。方法:45例PPHN患儿随机分为两组。A组23例,应用酚妥拉明,3mg·kg-1.次-1,3h内静脉点滴,使用1d。B组22例,应用硫酸镁饱和量200mg·kg-1,20~30min内静脉点滴,然后以20~50mg·kg-1·h-1维持量维持,一般使用1~3d。结果:A、B两组治疗前后肺动脉收缩压(PASP)明显下降,PaO2、OI、PO2(A-a)及临床症状明显改善,差异有极显著性(P<0.01),两组间治疗后各指标比较,差异无显著性(P均>0.05)。结论:酚妥拉明单次和硫酸镁多次给药均可使新生儿PASP下降,而酚妥拉明单次给药更简便、有效。更多还原

【Abstract】 OBJECTIVE To evaluate the effect of phentolamine on persistent pulmonary hypertension of newborn（PPHN）.METHODS Forty-five cases with PPHN were divided into two groups at random.A gGroup A（n=23） may bewas given with the treatment of phentolamine,3 mg·kg-1 per time in a day which may bewas injected in three hours.B gGroup B（n=22） may bewas given with the treatment which is constituted bysaturated MgSO4,200 mg·kg-1.The treatment will bewich was completed by i.v.drip infusion in twenty to thirty minutes.And,and the injection may last by then 20-50 mg·kg-1 per hour,which is used to be finished infor one to three days.RESULTS Pulmonary arterial systilic pressure（PASP） 、PaO2、OI、PO2（A-a）and clinical symptom be was improvedbetter significantly after the treatment.There was an obvious statistical significant（P<0.01） before and after treatment in group A and B.There were no significant differences after treatment between the two groups.CONCLUSION PASP of neonates can be decreased lowered by phentolamine at one timewith single administration and its therapeutic efficacy may be equals equivalent to the efficacy of multi-administration of MgSO₄ at many times.However,phentolamine injection in one time single administration may be an easy and effective therapyway.更多还原