【摘要】 目的研究布洛芬颗粒剂在大鼠体内药动学的昼夜节律特征。方法采用随机区组实验设计,将2组大鼠分别于9:00时和21:00时单次灌胃给予布洛芬颗粒剂50mg·kg-1,采用反相高效液相色谱法测定血药浓度,绘制药-时曲线,计算药动学参数。结果布洛芬颗粒剂不同时间给药血药浓度经时变化均符合一级消除动力学特征,药-时曲线拟合均为二房室模型。大鼠在暗期对布洛芬颗粒剂吸收快,达峰时间短;代谢快,消除半衰期短;峰浓度明显低于明期。结论大鼠在不同时间给予布洛芬颗粒剂,药动学参数存在昼夜节律的差异。更多还原

【Abstract】 OBJECTIVE To study the chrono-pharmacokinetics of ibuprofen granules in rats.METHODS A single oral administration of ibuprofen granules at the dose of 50 mg per kilogram was given to two group rats at 9:00 and 21:00, respectively, according to a randomized design. RP-HPLC method was used in the study. Concentration-time curves were obtained and the pharmacokinetic parameters were calculated.RESULTS The two-compartment model with first order elimination was used to describe the time course of ibuprofen granules in rats after a single-dose oral administration. Ibuprofen was absorbed quickly and tmaxwas short; metabolism was faster and t1/2β was shorter at night than that in the day time. ρmax was lower significantly in the day time. CONCLUSION The differences of circadian rhythm was shown about pharmacokinetic parameters in rats when ibuprofen was orally administered at the different time points.更多还原