【摘要】 目的研究雷尼酸锶的化学合成。方法以枸橼酸为起始原料,经过脱羧、酯化、环合、烷基化、水解成盐等多步反应生成终产物雷尼酸锶。结果雷尼酸锶的结构经IR,1H-NMR,13C-NMR得到证实,总产率约为42.6%。结论本合成路线操作简单、成本低,适合工业化生产。更多还原

【Abstract】 OBJECTIVE To study the synthesis route of strontium ranelate,an antiosteoporosis drug.METHODS Strontium ranelate was synthesized from citric acid via decarboxylation,esterification,cyclization,alkylation,hydrolysis and salification.RESULTS The structure of strontium ranelate was confirmed by IR,1H-NMR,13C-NMR,the total yield was 42.6% approximately.CONCLUSION The synthesis route was simple,low cost and could be used in industry.更多还原