【摘要】 目的探讨几种常见的风湿性疾病患者血中B细胞刺激因子(BAFF)的变化及临床意义。方法采用ELISA方法对各种风湿病患者及健康对照者血中BAFF进行测定。结果几种常见的风湿性疾病(SLE、RA、SS、AS)患者血中BAFF明显高于正常对照组;各组疾病患者血中BAFF的水平变化与各种疾病活动性指标呈明显相关改变。结论BAFF在风湿性疾病的发生发展中具有重要作用,抑制BAFF的产生或降低其水平可能成为风湿病治疗的有效方法之一。更多还原

【Abstract】 Objective To investigate the serum levels and clinical significance of B cell activating factor (BAFF) in some frequent rheumatic disease. Methods The serum levels of BAFF in rheumatic disease patients and normal controls were determined by ELISA. Results The serum levels of BAFF in frequent rheumatic disease were higher significantly than that of normal controls.In every kind of rheumatic disease,there was obvious correlation between the levels of BAFF and disease activity index. Conclusion BAFF plays a key role in the development of rheumatic disease. Inhibiting the production of BAFF and decreasing the levels of BAFF may be become one of available therapy for SLE.更多还原