【摘要】 目的探讨脑血管病患者发生阿司匹林抵抗(AR)概况及相关影响因素。方法67例病情稳定的脑血管病患者,每日服用阿司匹林100mg,连服7天,第8天晨起采取空腹静脉血,分别以二磷酸腺苷(ADP)、花生四烯酸(AA)为诱导剂,检测血小板聚集功能。结果用光学法测定血小板聚集功能,患者中AR发生率为10.4%(n=7),女性较多(72.3%∶41.5%,P=0.002),吸烟者亦较多(45.4%∶24.0%,P=0.01),与高血压同样存在相关性(37.5%∶24.8%,P=0.001)结论脑血管患者服用阿司匹林用于抗血小板治疗及预防中,若有AR存在可选用其他安全有效的抗血小板制剂,预测AR及抗血小板治疗个体化,将是抗血小板治疗的发展方向。更多还原

【Abstract】 Objective To investigate the accidence of aspirin resistance and associated affected factor in the patients with cerebrovascular disease.Methods 67 patients with stable cerebrovascular disease were asked to take aspirin orally for 7 days in the same dosage of 100mg/d.In the eighth morning;we detected these patients’ platelet aggregation function taking adenosine diphosphate(ADP) and arachidonic acid(AA) separately as revulsivum.Results Using the optical plateletaggregation(a widely accepted method),The prevalence of aspirin resistance was 10.4%(n = 7).in which women is more than men(72.3%vs41.5%,P=0.002) and smoker is more than non-smoker(45.4%vs24.0%,P=0.01).it also has connection with high blood pressure(37.5% vs24.8%,P=0.001).Conclusion Aspirin is used for patients who need to receive antiplatelet therapy or prevent artherosclerosis incidence.The doctors can choose other safe and effective antiplatelet drugs for the patients with AR or ASR.We think AR prediction and individuation will be the development trend of antiplatelet therapy.更多还原