【摘要】 以氰基胍和甲酸为原料,经成盐、环合反应得到5-氮杂胞嘧啶,5-氮杂胞嘧啶经硅烷化保护后,与乙酰化的核糖成苷,再脱保护基得到氮杂胞苷。目标化合物的结构经1H-NMR、MS谱数据确证,总收率为26.6%。该工艺路线优化了反应条件、简化了操作、提高了收率。更多还原

【Abstract】 Cyanoguanidine and acetylated β-D-ribose were used as starting materials to give target compound via salt formation,cyclization,silylation,coupling reaction and deprotection.The target compound was characterized by 1H-NMR,MS spectra and the total yield was 26.6%.The synthetic conditions were optimized and the total yield was increased.更多还原