【摘要】 目的:制备更昔洛韦肺部靶向微囊并测定其体外释放度。方法:以双乳化溶剂挥发法制备微囊;采用紫外分光光度法测定微囊的体外释药量,考察其体外释放度。结果:所制微囊外观圆整,平均粒径13.87μm;更昔洛韦检测浓度的线性范围为2～20μg·mL-1(r=0.999 9),平均回收率为99.96%(RSD=1.68%);包封率为63.85%,24h累积体外释放度约为40%。结论:更昔洛韦肺部靶向微囊具有良好的缓释性。更多还原

【Abstract】 OBJECTIVE: To prepare and establish a release rate method for the determination of ganciclovir lung-targeted microcapsules.METHODS: The microcapsules were prepared by compound emulsion-dispersion solvent evaporation method.The in vitro drug release amount and release rate of the microcapsules were detected by UV spectrophotometry.RESULTS: The microcapsules were regular in shape with an average particle size of 13.87 μm.The linear range of ganciclovir was 2～20 μg·mL-1(r=0.999 9) and its average recovery was 99.96%(RSD=1.68%).The entrapment efficiency of the microcapsules was 63.85% and the drug release amount in vitro reached 40% in 24 hours.CONCLUSIONS: The microcapsules show significant sustained release character.更多还原