【摘要】 目的:探讨铂类抗癌药的肾毒性机制。方法:12只大鼠均分为3组,分别按铂元素10mg·kg-1剂量静脉注射顺铂、卡铂和双环铂,采用原子吸收法测定并计算4h尿药累积排泄率及肾组织中浓度。结果:4h累积排泄率顺铂、卡铂、双环铂分别平均为(33.7±5.7)%、(89.1±8.5)%、(70.1±9.8)%,肾组织中铂的浓度分别为(70.6±31.6)、(217.7±97.6)、(278.8±112.0)μg.g-1。结论:与顺铂相比,双环铂与卡铂肾排泄较快,肾组织中的铂浓度相对较高;肾组织中铂浓度高低与肾毒性大小之间可能无直接关系。更多还原

【Abstract】 OBJECTIVE:To study the mechanism of renal toxicity of platinums in rats.METHODS:A total of 12 rats were equally assigned to receive cisplatin,carboplatin,or dicycloplatin i.v with the dosage of platinum at 10 mg·kg-1.The cumulative excretion rate of platinum in urine in 4 h and the concentration of platinum in renal tissue were measured by atom absorption method.RESULTS:The total excretion percent of platinum in urine in the first 4 h after injection of cisplatin,carboplatin,and dicycloplatin were(33.7±5.7)%,(89.1±8.5)% and(70.1±9.8)% respectively.The renal platinum concentration were 70.6±31.6,217.7±97.6,and(278.8±112.0)μg·g-1,respectively.CONCLUSIONS:Both the renal excretion speed and renal concentrations of platinum were higher for dicycloplatin and carboplatin than for cisplatin.The nephrotoxicity of platinum drugs probably has no direct relationship with the renal concentration of platinum.更多还原