【摘要】 目的:通过对大黄素在Caco-2细胞中摄取吸收的定量来考察其他游离大黄蒽醌类药物对大黄素吸收的影响。方法:建立了结合荧光检测器的高效液相色谱法用以检测Caco-2细胞中的大黄素的摄取量并初步探讨大黄素的吸收特性。结果:大黄素的吸收被芦荟大黄素、大黄素甲醚显著地抑制。结论:利用游离大黄总蒽醌中的其他成分与大黄素合理配伍用药或许可以有效的减少大黄中大黄素的毒性,提高中药大黄的安全性和有效性。更多还原

【Abstract】 AIM: To determine the influence of the absorption characteristics of emodin by the other free anthraquinones in human intestinal Caco-2 cells. METHODS: The intracellular concentrations of emodin were analyzed by a reverse-phase HPLC with Fluorescence Detector system to reveal the absorption characteristics of emodin. RESULTS: The absorption of emodin was reduced by aloe-emodin and physcion conspicuously. CONCLUSION: Results suggest that the mixture of emodin with other free total rhubarb anthraquinones (TRAs) could be more effectively and safely.更多还原